| 胍基丁胺对谷氨酸诱导PC12细胞DNA损伤的影响 |
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| 引用本文： | 宋明旭,杨吉成,盛伟华,王尉平. 胍基丁胺对谷氨酸诱导PC12细胞DNA损伤的影响[J]. 苏州科技学院学报(自然科学版), 2004, 21(1): 51-55 |
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| 作者姓名： | 宋明旭 杨吉成 盛伟华 王尉平 |
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| 作者单位： | 1. 苏州大学医学院,生物化学与分子生物学教研室,江苏,苏州,215006
2. 苏州大学,医学院细胞与分子教研室,江苏,苏州,215006 |
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| 摘 要： | 探讨了胍基丁胺对谷氨酸诱导PC12细胞DNA损伤的影响。在用一定浓度的谷氨酸诱导PC12细胞DNA断裂的同时，观察胍基丁胺对其DNA断裂和线粒体功能的影响，发现胍基丁胺能明显减轻谷氨酸诱导PC12细胞DNA断裂并能改善线粒体功能。这说明胍基丁胺具有抑制PC12细胞DNA损伤的作用，其机制可能与其拮抗NMDA受体，改善线粒体功能和减轻谷氨酸的氧化毒性有关。
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| 关 键 词： | 胍基丁胺 谷氨酸 DNA损伤 线粒体 |
| 文章编号： | 1672-0687(2004)01-0051-05 |
| 修稿时间： | 2003-09-01 |
Effect of Agmatine on Neuron DNA Injury Induced by Glutamate |
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| SONG Ming-xu,YANG Ji-cheng,SHENG Wei-hua,WANG Wei-ping. Effect of Agmatine on Neuron DNA Injury Induced by Glutamate[J]. Journal of University of Science and Technology of Suzhou, 2004, 21(1): 51-55 |
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| Authors: | SONG Ming-xu YANG Ji-cheng SHENG Wei-hua WANG Wei-ping |
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| Affiliation: | SONG Ming-xu1,YANG Ji-cheng2,SHENG Wei-hua2,WANG Wei-ping1 |
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| Abstract: | This paper aims to study the effect of agmatine on pc12 cell line injury. The method is to use glutamate with certain concentration to induce DNA injury of PC12 cell line and observe the effect of agmatine on DNA fragment and mitochondrial function simultaneously. It turns out that agmatine can inhibit PC12 cell line DNA injury induced by glutamate through block NMDA-R and improve mitochondrial function and reduce glutamate oxidative toxicity. |
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| Keywords: | agmatine: glutamate: DNA injury: mitochondrion? |
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