Genetic dissection of autoimmune type I diabetes in the BB rat. |
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Authors: | H J Jacob A Pettersson D Wilson Y Mao A Lernmark E S Lander |
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Affiliation: | Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142. |
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Abstract: | The BB rat is among the best models of insulin-dependent diabetes mellitus--with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance. |
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