| N-正丁基-苯甲酰-2-磺酰内亚胺对细胞膜流动性影响的研究 |
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| 引用本文： | 姜国华,刘忠敏.N-正丁基-苯甲酰-2-磺酰内亚胺对细胞膜流动性影响的研究[J].北京师范大学学报(自然科学版),1999,35(1):X1403. |
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| 作者姓名： | 姜国华 刘忠敏 |
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| 作者单位： | 北京师范大学分析测试中心,100875,北京 |
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| 摘 要： | 利用荧光偏振度法和激光拉曼光谱法研究了N-正丁基-苯甲酰-2-磺酰内亚胺对细胞膜流动性的影响，荧光探针偏振结果显示，它可提高红细胞膜的微粘度，并且存在剂量依赖关系；激光拉曼光谱的结果显示，它可提高I
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| 关 键 词： | N-正丁基-苯甲酰-2-磺酰内亚胺 细胞膜流动性 荧光偏振 激光拉曼光谱 |
| 修稿时间： | 1998-06-18 |
THE STUDY OF N-n-BUTYL-BENZOYL-2-SULPHIMIDE AFFECTING ERYTHROCYTE MEMBRANE FLUIDIT |
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| YJingGuohua,LiuZhongmin.THE STUDY OF N-n-BUTYL-BENZOYL-2-SULPHIMIDE AFFECTING ERYTHROCYTE MEMBRANE FLUIDIT[J].Journal of Beijing Normal University(Natural Science),1999,35(1):X1403. |
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| Authors: | YJingGuohua LiuZhongmin |
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| Institution: | YJingGuohuaLiuZhongmin;
(Analytical and Testing Center,Beijing NormalUniversity,100875,Beijing,China) |
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| Abstract: | The methods of fluorescence polarization and Laser-Raman spectra are used inthe studies of N- n- butyl-- benzoyl-- 2-- sulphimide affecting membrane fluidity.The fluorescence polarization measurement shows that N-n-butyl-benzoyl-2-sulphimide increasesmicroviscosity.Laser-Raman spectra shows that it increases the value of I2890/I2850 and I1130/I1087The results of the fluorescence polarization and Laser-Raman spectra show N-n-butyl-benzoyl-2-sulphimide decreases membrane fluidity.It becames easier that membrane isdestroied partly.It is guessed that N-n-butyl-benzoyl-2-sulphimide may decrease lipidbi-elayer fluidity between cuticalar cell and make lipidebilayer to be destroied partly,thus enhancingdrug absorbed through skin. |
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| Keywords: | N-n-butyl-benzoyl- 2- sulphimide membrane fluidity fluorescencepolarization Laser-Reman spedtra |
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