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Über die Brenzkatechinamine im Froschherzen und in der Froschhaut vor und nach Verabfolgung von α-Methyldopa
Authors:H Grobecker  P Holtz
Institution:(1) Pharmakologisches Institut der Universität, Frankfurt/Main, Deutschland
Abstract:Summary (1) The adrenalin of the frog heart was found to be localized mainly in the granular fraction (100,000g). After pretreatment with agr-methyldopa (agr-MD), the heart also contained agr-methyldopamine, agr-methylnoradrenalin, and agr-methyladrenalin. (2) agr-MD caused a maximal expansion of the melanophores. This action was counteracted byl-dopa, which per se caused a contraction of the melanophores. After pretreatment with agr-MD the skin contained besides adrenalin also agr-methyldopamine and agr-methyladrenalin. In addition also 5-hydroxytryptophan expanded the melanophores.
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