Über die Brenzkatechinamine im Froschherzen und in der Froschhaut vor und nach Verabfolgung von α-Methyldopa |
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Authors: | H Grobecker P Holtz |
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Institution: | (1) Pharmakologisches Institut der Universität, Frankfurt/Main, Deutschland |
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Abstract: | Summary (1) The adrenalin of the frog heart was found to be localized mainly in the granular fraction (100,000g). After pretreatment with -methyldopa (-MD), the heart also contained -methyldopamine, -methylnoradrenalin, and -methyladrenalin. (2) -MD caused a maximal expansion of the melanophores. This action was counteracted byl-dopa, which per se caused a contraction of the melanophores. After pretreatment with -MD the skin contained besides adrenalin also -methyldopamine and -methyladrenalin. In addition also 5-hydroxytryptophan expanded the melanophores. |
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