Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin |
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Authors: | W Lippmann |
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Institution: | (1) Biochemical Pharmacology Department, Ayerst Research Laboratories, P.O. Box 6115, H3C 3JI Montreal, Quebec, Canada |
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Abstract: | Summary Alrestatin at 25–1×10–4 M inhibited the accumulation of cyclic AMP induced by prostaglandin E2, but not theophylline, in the rat anterior pituitary in vitro. Somatostatin, at lower concentrations, inhibited both; maximal inhibition of the prostaglandin effect was greater with alrestatin. As cyclic AMP is considered to be a mediator in induced-hormonal release, it appears from the present findings that alrestatin may be of potential use in altering hormonal release.The author acknowledges the technical assistance of Miss C. Pilapil. |
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