| 色氨酸生物合成的多目标稳态优化 |
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| 引用本文： | 王晓雪,徐恭贤.色氨酸生物合成的多目标稳态优化[J].渤海大学学报(自然科学版),2011,32(2):114-119. |
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| 作者姓名： | 王晓雪 徐恭贤 |
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| 作者单位： | 渤海大学数理学院,辽宁锦州,121013 |
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| 基金项目： | 辽宁省博士科研启动基金资助项目 |
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| 摘 要： | 研究了色氨酸生物合成的多目标稳态优化.根据已建立的色氨酸生物合成过程模型,采用IOM方法,把多目标非线性优化问题转化为多目标线性优化问题来解决.在保证色氨酸产率的基础上,同时也使代谢物的浓度达到最低.仿真结果表明了优化算法的实用性和有效性.
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| 关 键 词： | 色氨酸生物合成 稳态优化 多目标 |
Stability optimization with multiple objectives for tryptophan biosynthesis |
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| WANG Xiao-xue,XU Gong-xian.Stability optimization with multiple objectives for tryptophan biosynthesis[J].Journal of Bohai University:Natural Science Edition,2011,32(2):114-119. |
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| Authors: | WANG Xiao-xue XU Gong-xian |
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| Institution: | WANG Xiao-xue,XU Gong-xian(College of Mathematics and Physics,Bohai University,Jinzhou 121013,China) |
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| Abstract: | In accordance with the given model of tryptophan biosynthesis and the method of IOM,the stability optimization with multiple objectives for tryptophan biosynthesis is studied by transforming nonlinear optimization with multiple objectives into linear optimization with multiple objectives.The minimal metabolite concentration is achieved when tryptophan productivity remains unchanged.The simulation experiment proves the practicality and effectiveness of the optimization algorithm. |
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| Keywords: | tryptophan synthesis stability optimization multiple objectives |
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