Effects of [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) on cyclic 3′,5′-nucleotide formation and phosphodiesterase activity |
| |
Authors: | T. A. Pugsley W. Lippmann |
| |
Affiliation: | (1) Biochemical Pharmacology Department, Ayerst Research Laboratories, P.O. Box 6115, H3C 3JI Montreal, Quebec, Canada |
| |
Abstract: | Summary The orally-effective antiallergic compound [N-(2-oxo-3,5,7-cycloheptatrien-1-yl)] aminooxoacetic acid ethyl ester (AY-25,674) exhibited a potency equivalent to or 3 times less than theophylline in inhibiting guinea-pig lung and beef heart PDE, respectively. AY-25,674 did not affect the basal activity of guinea-pig lung adenyl cyclase. Although part of the antiallergic activity of AY-25,674 may be due to the ability to elevate cyclic AMP levels by PDE inhibition, other modes of action appear to be of greater relevance.The authors acknowledge the excellent technical assistance of Ms M.T. Silvestre. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|