| 利用CRISPR/CAS9技术在生殖细胞中治愈小鼠遗传疾病(英文) |
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| 引用本文： | 李大力.利用CRISPR/CAS9技术在生殖细胞中治愈小鼠遗传疾病(英文)[J].中国科学通报(英文版),2015(3):400-402. |
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| 作者姓名： | 李大力 |
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| 作者单位： | Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University |
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| 摘 要： | The CRISPR/Cas system is a very powerful and versatile tool for genomic manipulation.A recent study published in Cell Research by Wu et al.1]reported a Cas9-mediated strategy to correct a disease-causing mutation in the mouse gamma C-crystallin(Crygc)locus in spermatogonial stem cells(SSCs)to cure the resulting cataracts disease in the offspring with 100%efficiency.Importantly,no off-target mutations were identified through whole-genome sequencing.
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| 关 键 词： | spermatogonial 遗传疾病 CRISPR/CAS9 sequencing offspring genomic powerful manipulation gamma locus |
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