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| Down-regulation of αGal epitopes by co-transfection of α1,3-galactosidase gene and α1,2–fucosyltransferase gene | |
| 作者姓名： | GONG Feng ZHANG Yangpei JIA Yanjun WANG Yingli TAN Yingxia & TIAN Shuguang Beijing Institute of Transfusion Medicine Beijing 100850 |
| 作者单位： | GONG Feng，ZHANG Yangpei，JIA Yanjun，WANG Yingli，TAN Yingxia & TIAN Shuguang Beijing Institute of Transfusion Medicine，Beijing 100850 |
| 摘 要： | Pig is considered the primary alternative species for xenotransplantation because of ethical considerations, breeding characteristics, infectious disease concerns, and its compatible size and physiology[1,2].A major barrier of pig-to-primate transplantation is the presence of terminal αGal epitopes on the surface of pig cells. αGal epitopes were formed by α1,3-galactosyltransferase (α1,3-GT) catalysis[3,4]. Humans and Old World monkeys have lost the corresponding α1,3-GT activity in th… |
| 关 键 词： | xenotransplantation αGal epitopes α1-3-galactosidase α1-2-fucosyltransferase. |
| 本文献已被 CNKI 等数据库收录！ | |