| 菟丝子提取物对PC12细胞中GAP-43表达影响 |
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| 引用本文： | 刘建辉,殷菲,包永明,姜波,安利佳.菟丝子提取物对PC12细胞中GAP-43表达影响[J].大连理工大学学报,2004,44(3):378-382. |
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| 作者姓名： | 刘建辉 殷菲 包永明 姜波 安利佳 |
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| 作者单位： | 大连理工大学,生物工程系,辽宁,大连,116024;复旦大学，医学神经生物学国家重点实验室，上海，200032;大连理工大学,精细化工国家重点实验室,辽宁,大连,116012;大连理工大学,生物工程系,辽宁,大连,116024 |
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| 摘 要： | 以常用的PC12细胞株为实验模型，分析了菟丝子提取物作用后PC12细胞突触延伸情况；同时结合免疫细胞化学和Western blot方法考察了其对神经细胞突触可塑性信号分子GAP-43表达的影响．研究结果表明，以黄酮甙为主要成分的菟丝子提取物不仅能诱导PC12细胞分化、突触延伸，而且还能促进GAP-43的表达．
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| 关 键 词： | 菟丝子 突触 生长相关蛋白 提取物 |
| 文章编号： | 1000-8608(2004)03-0378-05 |
Effect of C.chinensis extract on expression of GAP-43 in PC12 cells |
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| LIUJian-hui.Effect of C.chinensis extract on expression of GAP-43 in PC12 cells[J].Journal of Dalian University of Technology,2004,44(3):378-382. |
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| Authors: | LIUJian-hui |
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| Institution: | LIUJian-hui~ |
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| Abstract: | To explore the effect of C. chinensis on rat pheochromocytoma PC12 cells, the neurite outgrowth in PC12 cells was analyzed. The expression of the growth associated protein 43 (GAP-43), an intrinsic determinant of neuronal development and plasticity, was also researched with immunocytochemistry and Western blot. The results show that C. chinensis extract can not only increase the proportion of neurite-bearing cells in PC12 cells, but also promote the expression of GAP-43. |
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| Keywords: | C chinensis neurite growth associated protein extract |
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