| 青霉素扩环半合成头孢菌素研究进展 |
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| 引用本文： | 郭晓强,甘亚,张信中,颜军,姚倩.青霉素扩环半合成头孢菌素研究进展[J].成都大学学报(自然科学版),2010,29(3):199-204. |
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| 作者姓名： | 郭晓强 甘亚 张信中 颜军 姚倩 |
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| 作者单位： | 成都大学,生物产业学院,四川,成都,610106;中国医药集团,四川抗菌素工业研究所有限公司,四川,成都,610051 |
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| 摘 要： | 以青霉素为原料经过化学方法扩环半合成头孢菌素中间体包括7-ADCA、GCLE(GCLH)、3-羟基头孢烯、3-环外亚甲基头孢烷酸和丙二烯羧酸酯类氮杂环丁酮.在此基础上综述了各中间体合成相关头孢菌素品种,以及由青霉素扩环制备头霉素和1-氧头孢菌素的研究进展.同时,针对目前该领域的发展状况提出了适合国情的由青霉素半合成头孢菌素一些思路和建议.
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| 关 键 词： | 青霉素G 头孢菌素 半合成 扩环 |
Research Progress of Semi-synthetic Cephalosporin by Ring-expansion of Penicillin G |
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| GUO Xiaoqiang,GAN Ya,ZHANG Xinzhong,YAN Jun,YAO Qian.Research Progress of Semi-synthetic Cephalosporin by Ring-expansion of Penicillin G[J].Journal of Chengdu University (Natural Science),2010,29(3):199-204. |
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| Authors: | GUO Xiaoqiang GAN Ya ZHANG Xinzhong YAN Jun YAO Qian |
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| Institution: | GUO Xiaoqiang1,GAN Ya1,ZHANG Xinzhong2,YAN Jun1,YAO Qian1(1.School of Bioindustry,Chengdu University,Chengdu 610106,China,2.Sichuan Industrial Institute of Antibiotics,China National Pharmaceutical Group Corporation,Chengdu 610052,China) |
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| Abstract: | Penicillin G is often utilized as an economical starting material to synthesize cephalosporin,which needs many intermediates,such as 7-ADCA,GCLE,GCLH,3-exomethylenecepham,allene carboxylate's azetidinone.Varieties of cephalosporin which are synthesized by various intermediate products were reviewed as well as the progress of preparing cephamycin and 1-oxygen cephalosporin by these intermediates.At the same time,in the light of the current developing situation of this field,some ideas and suggestions for sem... |
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| Keywords: | penicillin G cephalosporin semi-synthetic ring enlargement |
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