| P73蛋白在胃炎、不典型增生和胃癌中的表达及意义 |
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| 引用本文： | 李忆岚,;邹益友,;刘功成,;刘剑波,;李衍军. P73蛋白在胃炎、不典型增生和胃癌中的表达及意义[J]. 湘南学院学报(自然科学版), 2008, 0(2): 24-26 |
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| 作者姓名： | 李忆岚, 邹益友, 刘功成, 刘剑波, 李衍军 |
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| 作者单位： | [1]郴州市第一人民医院消化内科,湖南郴州423000; [2]中南大学湘雅医院,湖南长沙410078 |
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| 摘 要： | 目的探讨p73基因在胃癌发生、发展中的作用和意义。方法采用免疫组化技术检测胃炎、轻度不典型增生、中重度不典型增生和胃癌（均为外科手术患者）各30例组织中p73蛋白的表达。结果p73蛋白在胃癌组和不典型增生组中表达高于胃炎组，胃癌组中表达高于不典型增生组（P〈0．05）；p73蛋白的阳性表达率在胃癌的不同的分化度之间有差异，低分化腺癌组织中的阳性表达强度高于高、中分化腺癌（P〈0．05），p73蛋白在中、重度不典型增生组的阳性表达率与轻度不典型增生组无显著差异（P〉0．05）；在胃癌的不同TNM分期之间也有差异（P〈0．05），并且TNM分期越高，阳性表达率越高；均与淋巴结转移、肿瘤部位、胃癌侵及层次、肿瘤大小无关（P〉0．05）。结论p73的高表达可能参与了胃癌发生、发展，作为胃癌发生、发展及预后的肿瘤指标物。
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| 关 键 词： | p73 不典型增生 胃癌 |
Expression and Clinical Significance of p73 in Gastritis,Gastric Dysplasiapatients and Gastric Cancer |
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| Affiliation: | LI Yi-lan, ZOU Yi-you, LIU Gong-cheng, et al (Department of Gastroenterology, the First Renmin Hospital of Chenzhou, Chenzhou, Hunan 423000, China) |
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| Abstract: | Objective To assess the expression of p73 development of gastric cancer. Methods Expression of p73 in 30 gastric tissues,30 atypical hyperplasia Ⅰ tissues, 30 atypical hyperplasia Ⅱ -Ⅲ tissues and 30 gastric cancer tissues were detected by
immunohistochemistry. Results The expression of p73 in the gastric dysplasiapatients and gastric cancer was stronger than it in the gastritis （P 〈 0.05）. The expressions of p73 were related with differentiation of gastric cancer, the expressions of p73 in low - differentiated adenocarcinoma were stronger than in moderate - well - different - tiated adenocarcinoma （P 〈 0.05）. The p73 expressions were significantly associated with TNM classification of gastric cancer （P 〈 0.05）, were not correlated with node - metastasis, tumor site, depth of invasio, tumor size （ P 〉 0.05）. Conclusions The results indicate that p73 may play a significant role in carcinogenesis and development of gastric cancer, and may act as novel biological marker of the prognosis in gastric cancerpatients. |
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| Keywords: | p73 Dysplasiapatients Gastric cancer |
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