Neither prolactin nor growth hormone restore the nocturnal rise in pineal N-acetyltransferase activity or melatonin content in hypophysectomized rats |
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| Authors: | Dr I Sabry R J Reiter |
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| Institution: | (1) Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, 78284-7763 Texas, San Antonio, USA;(2) Present address: Faculty of Science, Department of Zoology, Alexandria University, Alexandria, Egypt |
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| Abstract: | Summary Hypophysectomy in adult male rats greatly attenuated the nocturnal rise in both pineal N-acetyltransferase (NAT) activity and melatonin content. High nighttime levels of NAT and melatonin were not restored by treating the animals with either prolactin or growth hormone, alone or in combination. Treating intact rats with bromocriptine, which depresses circulating prolactin levels, also was without effect on pineal melatonin synthesis. It appears that neither prolactin nor growth hormone are of major importance in determining pineal melatonin production. |
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| Keywords: | Pineal gland hypophysectomy N-acetyltransferase melatonin prolactin growth hormone |
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