Endothelin |
| |
Authors: | Yoshifumi Kawanabe Surya M Nauli |
| |
Institution: | (1) Department of Neurosurgery, Otsu Municipal Hospital, 2-9-9 Motomiya, Otsu Shiga, 520-0804, Japan;(2) Department of Pharmacology, The University of Toledo, Toledo, OH 43606, USA |
| |
Abstract: | Endothelin-1 is the most potent vasoconstrictor agent currently identified, and it was originally isolated and characterized
from the culture media of aortic endothelial cells. Two other isoforms, termed endothelin-2 and endothelin-3, were subsequently
identified, along with structural homologues isolated from the venom of Actractapis engaddensis known as the sarafotoxins. In this review, we will discuss the basic science of endothelins, endothelin-converting enzymes,
and endothelin receptors. Only concise background information pertinent to clinical physician is provided. Next we will describe
the pathophysiological roles of endothelin-1 in pulmonary arterial hypertension, heart failure, systemic hypertension, and
female malignancies, with emphasis on ovarian cancer. The potential intervention with pharmacological therapeutics will be
succinctly summarized to highlight the exciting pre-clinical and clinical studies within the endothelin field. Of note is
the rapid development of selective endothelin receptor antagonists, which has led to an explosion of research in the field. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|