维拉帕米对肺静脉急性电重构的影响

探讨维拉帕米对短阵快速剌激肺静脉后肺静脉有效不应期及有效不应期频率适应性的影响。对8条成年杂种犬采用自身前后对照的方法,第一部分实验:首先分别测量起搏周长(PCL)分别为300 ms、400 ms时肺静脉有效不应期(PV-ERP),接着以1:1起搏肺静脉的最快频率刺激肺静脉10 min,分别在刺激中止后即刻、5 min、10 min时重复测量PV-ERP。第二部分实验:完成上述实验后15 min给予维拉帕米,再次重复第一部分实验内容。结果:短阵快速刺激肺静脉可以引起PV-ERP明显缩短,PV-ERP频率适应性下降,即肺静脉发生了急性电重构,应用维拉帕米后虽然不能逆转上述改变,但是明显减小改变的程度。说明维拉帕米一定程度上抑制了肺静脉急性电重构的程度。

The Effect of Verapamil on Pulmonary Vein Acute Electrical Remodeling

To investigate the effect of verapamil on pulmonary vein effective refractory period after short rapid stimulating pulmonary vein, 8 adult hybrid dogs are adopt self-contrast method. The first step: basic PV-ERP(PCL 400 ms,300 ms) was measured firstly. Stimulated distal pulmonary vein ten minutes by maximum frequency that 1:1 pacing pulmonary vein. PV-ERP was remeasured immediately, 5 min and 10 min, respectively. The second step: the verapamil was gived when the above experiment was completed. Then the first step experiment was repeated. It is resulted that short rapid stimulating pulmonary vein resulted in the shorten of pulmonary vein effective refractory period and pulmonary vein effective refractory period rate adaptability decreased, pulmonary vein acute electrical remodeling recovered in 10 minutes. The changing could not inversio, but the degree of changing decreased after giving verapamil. verapamil decrease the level of pulmonary vein acute electrical remodeling.