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| 类脂液晶中PC对MO构象影响及释放行为 | |
| 引用本文： | 刘少杰,迟卫东,陆玮洁,李真.类脂液晶中PC对MO构象影响及释放行为[J].山东大学学报(理学版),2010,45(1):10-16. |
| 作者姓名： | 刘少杰 迟卫东 陆玮洁 李真 |
| 作者单位： | 1. 山东大学胶体与界面化学教育部重点实验室,山东,济南,250100;山东省胶体材料工程技术研究中心,山东,济南,250100 2. 山东大学胶体与界面化学教育部重点实验室,山东,济南,250100;烟台大学,山东,烟台,265000 3. 山东大学胶体与界面化学教育部重点实验室,山东,济南,250100 |
| 摘 要： | 利用傅立叶变换红外光谱(FT-IR)技术研究了盐酸普鲁卡因(PC)对类脂立方液晶中甘油单油酸酯(MO)分子构象的影响。研究表明,PC对MO分子疏水部分的影响较大,同时促进了MO分子极性头中羰基的氢键作用,证明PC可以参与形成脂质双层膜。同时研究了PC在MO/水立方液晶中的释放行为,发现PC浓度不同时,其释放行为相似,释放的两个阶段都符合Higuchi平方根定律。 |
| 关 键 词： | 盐酸普鲁卡因 类脂立方液晶 FT-IR 药物释放 |
| 收稿时间： | 2009-07-02 |
Effects of procaine hydrochloride on the molecular conformation of monoolein and drug release behavior in the cubic phase |
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| LIU Shao-jie,CHI Wei-dong,LU Wei-jie,LI Zhen.Effects of procaine hydrochloride on the molecular conformation of monoolein and drug release behavior in the cubic phase[J].Journal of Shandong University,2010,45(1):10-16. | |
| Authors: | LIU Shao-jie CHI Wei-dong LU Wei-jie LI Zhen |
| Institution: | LIU Shao-Jie, CHI Wei-Dong, LIU Wei-Jie, LI Zhen：Key Laboratory of Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan 250013, Shandong, China; LIU Shao-Jie： Engineering research Center for Colloid Materials of Shandong Province, Jinan 250100, Shandong, China; CHI Wei-Dong： Yantai University, Yantai 265000, Shandong, China |
| Abstract: | The effect of procaine hydrochloride (PC) on the molecular conformation of monoolein in the cubic liquid crystalline phase was studied by FT-IR. It was found that the conformation of the hydrophobic group of monoolein was strongly affected by PC, and the H-bond between MO and PC could induce a change of the vibrations of C = O bond in the polar group of the MO. The release behaviors of PC from MO/water cubic phases with different PC contents were after investigation found to be similar and corresponded to the Higuchi quarter root law. |
| Keywords: | FT-IR procaine hydrochloride cubic liquid crystalline FT-IR drug release |
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