| 耐热碱性磷酸酯酶(FD-TAP)的三维结构分析 |
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| 引用本文： | 戴林森,王健,高大操,季朝能,盛小禹,毛裕民. 耐热碱性磷酸酯酶(FD-TAP)的三维结构分析[J]. 复旦学报(自然科学版), 2000, 39(4): 394-396 |
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| 作者姓名： | 戴林森 王健 高大操 季朝能 盛小禹 毛裕民 |
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| 作者单位： | 1. 复旦大学分析测试中心
2. 复旦大学生命科学院 |
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| 基金项目： | 国家自然科学基金资助项目!(39870 40 2 ) |
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| 摘 要： | 有计算机图像模拟，能量极小化和分子动力学方法，以大肠杆菌碱性到酯酶（ＢＡＰ）为主要结构模板，构建了耐热碱性到酯酶（ＦＤ－ＴＡＰ）的三维结构，并分析了它的结构特征，从而为酶蛋白的结构、催化反应活性和热稳定性间关系的进一步研究打下了很好的基础。
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| 关 键 词： | 磷酸酯酶 同源模建 三维结构分析 工具酶 |
Analysis of 3D Structrue of the Thermostable Alkaline Phosphatase(FD-TAP) |
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| DAI Lin-sen,WANG Jian,GAO Da-cao,JI Chao-neng,SHENG Xiao-yu,MAO Yu-min. Analysis of 3D Structrue of the Thermostable Alkaline Phosphatase(FD-TAP)[J]. Journal of Fudan University(Natural Science), 2000, 39(4): 394-396 |
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| Authors: | DAI Lin-sen WANG Jian GAO Da-cao JI Chao-neng SHENG Xiao-yu MAO Yu-min |
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| Affiliation: | 1.Center of Analysis and Measurement; 2. School of Life Sciences |
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| Abstract: | The 3D structure of thermostable alkaline phosphatase(FD TAP) has been modeled, taking Escherichia coli alkaline phosphatase(BAP) as the main structure templet and using computer graphics simulation, energy minimization and molecular dynamics. Its structure character has also been alalysed. These are the good foundation for further study on the relationship among the structure, catalytic reaction activity and thermostability of FD TAP. |
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| Keywords: | thermostable alkaline phosphatase homology modeling active center |
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