Subtypes of protein kinase C in rat cerebral microvessels |
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| Authors: | H Kobayashi T Mizuki Y Koda M Okazaki A Kuroiwa F Izumi |
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| Institution: | Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. |
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| Abstract: | Protein kinase C in rat cerebral microvessels was characterized. By hydroxyapatite column chromatography, protein kinase C in the soluble fraction was resolved into two major peaks corresponding to type II and III enzymes, in the proportion of 57% and 38%, respectively. Since each subtype is considered to have a distinct role, the high proportion of type II enzyme found in this study suggests that this type may be involved in specific functions of the cerebral microvessels. |
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