(1) Present address: Laboratoire de Physiologie, U. E. R. de Pharmacie, 91, rue Leyteire, F-33000 Bordeaux, (France);(2) Laboratoires de Biochimie et Pharmacodynamie, U.E.R. de Pharmacie, 91, rue Leyteire, F-33000 Bordeaux, (France)
Abstract:
Summary Parallel variations in plasma and urine variations of endogenous urea and creatinine level in the rat during 4 consecutive 6-h-long periods permit to evidence urea and creatinine clearance diurnal variations with very significant increase in the 2 nightly periods. The signification of this very large nightly glomerular filtration increase is discussed.