Distribution of cytoskeletal elements in cultured skin fibroblasts of patients with Duchenne's Muscular Dystrophy |
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| Authors: | E Rungger-Brändle S Liechti-Gallati G Gabbiani H Moser N Herschkowitz |
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| Institution: | (1) Department of Pathology, University of Geneva, CH-1211 Geneva 4, (Switzerland);(2) Departments of Pediatrics, University of Berne, CH-3010 Berne, (Switzerland) |
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| Abstract: | Summary Cultured fibroblasts from patients suffering from Duchenne's Muscular Dystrophy were examined by indirect immunofluorescent techniques using antibodies against actin, myosin, tubulin, and intermediate-sized filaments. The cells display normal patterns of microfilamentous bundles (stress fibres), microtubules, and intermediate-sized filaments suggesting a normal organization of these cytoskeletal structures.Acknowledgments. This work was supported by the Swiss National Science Foundation, grant Nos 3.445-0.79 and 3.419.78. |
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