Involvement of p34cdc2 in establishing the dependency of S phase on mitosis |
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| Authors: | D Broek R Bartlett K Crawford P Nurse |
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| Institution: | Biochemistry Department, University of Oxford, UK. |
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| Abstract: | Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles. |
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