Antagonistic activity of galanthamine on constant infusion of pancuronium in rats |
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| Authors: | D A Cozanitis Francien van de Pol H van Wezel J F Crul |
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| Institution: | (1) Department of Anaesthesiology, Catholic University of Nijmegen, Geert Grooteplein zuid 12, Nijmegen, (The Netherlands);(2) Present address: Department of Anaesthesia, Helsinki University Central Hospital, SF-00290 Helsinki 29, Finland |
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| Abstract: | Summary The effect of galanthamine, an anticholinesterase having a tertiary ammonium group, on a constant infusion of pancuronium was studied in the rat tibialis anterior-sciatic nerve preparation. The results were compared with those previously obtained with neostigmine, pyridostigmine, and 4-aminopyridine. The antagonizing activity of galanthamine is similar to that of 4-aminopyridine and less than that of the other 2 anticholinesterases. The duration of galanthamine antagonism is similar to that of neostigmine and pyridostigmine but less than that of 4-aminopyridine. |
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