Effects of L-aspartic acid,L-asparagine and/or L-asparaginase on forced swimming-induced immobility,analgesia, and decrease in rectal temperature in rats |
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Authors: | H Koyuncuoĝlu L Eroĝlu T Altuĝ |
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Institution: | (1) Max-Planck-Institut für experimentelle Medizin, D-3400 Göttingen, (Federal Republic of Germany);(2) Department of Pharmacology and Clinical Pharmacology, Istanbul Medical Faculty, Istanbul, (Turkey) |
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Abstract: | Summary The effect of L-aspartic acid, L-asparagine and/or L-asparaginase were compared with those of imipramine on immobility, number of defecations, increase of nociceptive threshold, and hypothermia, induced by forced swimming in rats. L-Aspartic acid was found to be as effective as imipramine in reducing the effects of forced swimming, presumable by normalizing the decreased level of endogenous L-aspartic acid, due to the inhibition of L-asparaginase activity and/or by stimulated the inhibited enzyme. The other treatments antagonized the immobility, but not the increased number of defecations. All compounds abolished the elevation of nociceptive threshold and hypothermia. |
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