Primary structure and functional expression from complementary DNA of the rod photoreceptor cyclic GMP-gated channel |
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| Authors: | U B Kaupp T Niidome T Tanabe S Terada W B?nigk W Stühmer N J Cook K Kangawa H Matsuo T Hirose |
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| Affiliation: | Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan. |
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| Abstract: | The complete amino-acid sequence of the cyclic GMP-gated channel from bovine retinal rod photoreceptors, deduced by cloning and sequencing its complementary DNA, shows that the protein contains several putative transmembrane segments, followed by a region that is similar to the cyclic GMP-binding domains of cyclic GMP-dependent protein kinase. Expression of the complementary DNA produces cyclic GMP-gated channel activity in Xenopus oocytes. |
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