| 2-吡啶甲醇的合成研究 |
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| 引用本文： | 桂伦,郑典模,叶焕英,刘辉.2-吡啶甲醇的合成研究[J].江西科学,2009,27(5):767-770. |
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| 作者姓名： | 桂伦 郑典模 叶焕英 刘辉 |
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| 作者单位： | 南昌大学环境与化学工程学院,江西,南昌,330031 |
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| 摘 要： | 2-吡啶甲醇不仅是一种新开发的治疗心血管疾病药物的中间体,也是很多重要药物的中间体。介绍以2-甲基吡啶为原料,经氧化,酰化重排,水解制备2-吡啶甲醇的工艺路线。简述了反应的机理、合成方法及研究进展,并对影响反应的各种因素进行了比较。
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| 关 键 词： | 2-吡啶甲醇 乙酸2-吡啶基甲酯 吡啶氧化物 |
Synthesis of 2-pyridine Methanol |
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| GUI Lun,ZHENG Dian-mo,YE Huan-ying,LIU Hui.Synthesis of 2-pyridine Methanol[J].Jiangxi Science,2009,27(5):767-770. |
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| Authors: | GUI Lun ZHENG Dian-mo YE Huan-ying LIU Hui |
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| Institution: | (School of Environmental and Chemical Engineering, Nanchang University,Jiangxi Nanchang 330031 PRC) |
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| Abstract: | 2-pyridinemethanol is not only an drug intermediates of the newly developed of treatment of cardiovascular diseases intermediates,but also many important drug intermediates. This paper describes the process route,which takes 2-methylpyridine as the raw material for the preparation of 2- pyridinemethanol through oxidation, rearrangement acylation, hydrolysis, etc. This paper mainly summarizes the reaction mechanism, synthesis methods and research progress. And a variety of factors affect the reaction are compared. |
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| Keywords: | 2-pyconol 2-pyridylcarbinol acetate Pyridine N-oxides |
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