Biochemistry of frog ribonucleases |
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| Authors: | M Irie K Nitta T Nonaka |
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| Institution: | (1) Department of Microbiology, Hoshi College of Pharmacy, Ebara 2-4-41, Shinagawa-ku, Tokyo 142 (Japan), JP;(2) Cancer Research Institute, Tohoku College of Pharmaceutical Sciences, Komatsushima 4-4-1, Sendai 981 (Japan), JP;(3) Nagaoka University of Technology, Kamitomioka 1603-1, Nagaoka, Niigata 940-21 (Japan), JP |
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| Abstract: | Frogs have unique pyrimidine base-specific RNases, with structures similar to those of turtle, iguana and chicken RNases.
Among the four frog RNases discussed here, three from Rana pipiens, R. catesbeiana and R. japonica oocyte cells show anti-tumour activity, and the latter two show lectin activity towards sialic acid-rich glycoproteins. In
this review, (i) we compare their unique primary structures with respect to the locations of their disulphide bridges, three-dimensional
structure, base specificity and heat stability as compared with RNase A, and (ii) we summarize current knowledge about the
mode of action of lectin and the antitumour activities of the three frog RNases. |
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| Keywords: | , Frog RNase, lectin activity, antitumour activity, pyrimidine base-specific RNase, amphibian RNase, |
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