Inhibition of cytosolic rat hepatic glutathione S-transferase activities by bromosulfophthaleins |
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| Authors: | A J Baars M Jansen S Arnoldussen K L de Lussanet de la Sablonière D D Breimer |
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| Institution: | (1) Department of Pharmacology, Subfaculty of Pharmacy, Sylvius Laboratories, University of Leiden, P.O. Box 9503, NL-2300 RA Leiden, (The Netherlands) |
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| Abstract: | Summary The enzymatically catalyzed conjugation of glutathione with 1-chloro-2,4-dinitrobenzene and styrene-7,8-oxide is inhibited by tetrabromosulfophthalein in a non-competetive way, although tetrabromosulfophthalein itself is a substrate for glutathione S-transferases. Dibromosulfophthalein, which is not a substrate for glutathione S-transferases, inhibits the 1-chloro-2,4-dinitrobenzene conjugation competetively and the styrene-7,8-oxide conjugation non-competetively. |
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