Dystrophic mice show age related muscle fibre and myelinated axon losses

Although many differences between age matched normal and dystrophic animals have been found, there have been few demonstrations of a time related quantitative change from normal to a characteristically dystrophic situation within the dystrophic strain itself. Here we report such a change-normal numbers of muscle fibres present in young dystrophic mice were rapidly lost, such that older animals showed the reduced number of muscle fibres characteristic of murine dystrophy. Although these losses began after a demonstrable loss of myelinated axons had occurred, it is not possible to say if the loss of muscle fibres was a result of the loss of nerve fibres.