高尔基体蛋白功能研究进展

高尔基体蛋白是一类定位在高尔基体表面上的螺旋卷曲蛋白家族.目前研究最为广泛的有11种高尔基体蛋白,它们分别定位在高尔基体堆栈不同的部位上.其中有3种定位在高尔基体正面膜囊表面上,高尔基体的反面膜囊表面和高尔基体膜囊边缘表面各定位4种高尔基体蛋白,它们以各自肽链羧基端或以跨膜结构域或与小的GTPase结合锚定到高尔基体膜表面.目前它们比较明确的主要功能是参与维持高尔基体结构的稳定和胞质内的膜运输,还有很多重要的功能在持续地研究发掘中.该文综述了这11种高尔基体蛋白功能的最新研究进展,以期为研究人员在该领域中更深入地进行研究提供参考.

The Research Advances in Function of Golgins

Golgins are a family of coiled-coil proteins which is located on the surface of the Golgi apparatus.Currently,there are 11 Golgins that are most widely studied.They are located in different parts of the Golgi stacks.Three of them are located on the surface of cis-Golgi,and four kinds of Golgins are located on the surface of the trans-Golgi and Golgi rims,respectively.They are anchored to the Golgi membrane surface by their own carboxyl end of peptide chain,or by trans-membrane domain,or by binding with small GTPase.At present,it is certainly that their main function is to participate in maintaining the stability of the Golgi structure and membrane traffic in the cytoplasm.They also have many important functions that are still under continuous research and exploration.The latest research progress on the functions of these 11 Golgins is comprehensively reviewed in this paper,hoping to provide references for researchers to further study on this field.