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Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs |
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| Authors: | Salmon Hillbertz Nicolette H C Isaksson Magnus Karlsson Elinor K Hellmén Eva Pielberg Gerli Rosengren Savolainen Peter Wade Claire M von Euler Henrik Gustafson Ulla Hedhammar Ake Nilsson Mats Lindblad-Toh Kerstin Andersson Leif Andersson Göran |
| Affiliation: | Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences (SLU), Biomedical Centre, Box 597, SE-751 24 Uppsala, Sweden. |
| Abstract: | The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development. |
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