| Regulations of Thyroid Hormone on Cardiac Protein Kinase C Signal Pathway in vitro |
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| 作者姓名： | WANGBao-hua OUYANGJing-ping LIUYong-min ZHENGHan-qiao LIYin-ping |
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| 作者单位： | [1]SchoolofMedicine,WuhanUniversity,Wuhan430071,Hubei,China [2]SchoolofMedicine,WuhanUniversity,Wuhan430071,Hubei,China |
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| 基金项目： | SupportedbytheNaturalScienceFoundationofHubeiProvince(980 91 ) |
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| 摘 要： | The experiments were conducted to assess the influences of thyroid hormone on cardiac protein kinase C(PKC) signal pathway with cultured cardiac myocytes and fibroblasts as the models. Cells were pretreated with 1% newborn calf serum (NCS) or angiotensin Ⅱ (Ang Ⅱ), and then following by a triiodothyronine (T3) treatment. The PKC activity, PKCa and PKCε expressions were analyzed and compared. In 1% NCS pretreatment, T3 could inhibit PKC activity and PKCε expression in cardiac myocytes. The AngⅡ pretreatment led to an increase of PKC acUvity and PKCε expression in cardiac myocytes, and an increase of PKC activity in cardiac fibroblasts. Following by T3 treatment, the increased PKC activity and PKCε expression in cardiac myocytes were markedly decreased. In conclusion, whether in 1% NCS or in Ang lI pretreatment, T3 could inhibit PKC activity and PKCε expression in cardiac myocytes.
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| 关 键 词： | 甲状腺激素 心肌细胞 蛋白激酶C 信号转导 心脏成纤维细胞 |
Regulations of Thyroid Hormone on Cardiac Protein Kinase C Signal Pathway in vitro |
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| WANGBao-hua OUYANGJing-ping LIUYong-min ZHENGHan-qiao LIYin-ping.Regulations of Thyroid Hormone on Cardiac Protein Kinase C Signal Pathway in vitro[J].Wuhan University Journal of Natural Sciences,2004,9(4):522-526. |
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| Abstract: | |
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| Keywords: | thyroid hormone cardiac myocytes cardiac fibroblasts protein kinase C |
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