Histamine-induced hypotension modified by H1 and H2 antagonists in the monkey (Macaca mulatta) |
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| Authors: | T. F. Doyle T. A. Strike |
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| Affiliation: | (1) Department of Neurobiology, Armed Forces Radiobiology Research Institute, 20014 Bethesda, Maryland, USA;(2) Present address: Baltimore Cancer Research Center, Division of Cancer Treatment, National Cancer, Institute, 20014 Bethesda, Maryland, USA |
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| Abstract: | Summary Blocking H2 receptors with burimamide in the dose used (20 mg/kg) approximately doubles the amount) of histamine needed to produced the same effect as seen when H1 antagonists (chlorpheniramine or mepyramine) are used alone. TheK2 ratios for chlorpheniramine-chlorpheniramine plus burimamide are 117–204 and for mepyramine-mepyramine phus burimamide are 200–478. H1 and H2 receptors, in the monkey, when stimulated, both cause cardiovascular responses in the same direction. |
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