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Detecting chimeric 5'l3'UTRs with cross-chromosomal splicing by bioinformatics |
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| Authors: | ZHANG Zhihua ZHANG Yong SHI Baochen DENG Wei ZHAO Yi CHEN Runsheng Institute of Biophysics Chinese Academy of Sciences Beijing China Institute of Computing Technology Chinese Academy of Sciences Bejing China Correspondence should be addressed to Chen Runsheng |
| Affiliation: | ZHANG Zhihua,,ZHANG Yong,,SHI Baochen,,DENG Wei,,ZHAO Yi,,CHEN Runsheng Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China Institute of Computing Technology,Chinese Academy of Sciences,Bejing 100080,China Correspondence should be addressed to Chen Runsheng |
| Abstract: | The 5'/3' UTRs of mRNA are crucial in transla-tional regulation, and several serious diseases are believed tobe associated with abnormal splicing of these parts of themRNA sequence. In this work a novel method which usessequence alignment database searching for detecting chi-meric 5'3' UTRs with cross-chromosomal splicing is reported.Eight highly credible instances of cross-chromosomal splic-ing have been found using this method, representing addi-tional confirmation of the existence of cross-chromosomalsplicing events provided by bioinformatics tools. Since noconserved motif has been found in any of the eight instances,and at the same time current prediction algorithms produceonly trivial secondary structures at the "splicing sites", it isnot possible to identify any specific signal leading to thesplicing. |
| Keywords: | 5'/3' UTRs mRNA trans-splicing chromosomal translocations chimeric |
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