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| 压力对超临界流体技术制备药物微粒的影响 | |
| 引用本文： | 陈岚 张岩 李保国 伍贻文 华泽钊 刘哲鹏. 压力对超临界流体技术制备药物微粒的影响[J]. 上海理工大学学报, 2004, 26(3): 220-223 |
| 作者姓名： | 陈岚 张岩 李保国 伍贻文 华泽钊 刘哲鹏 |
| 作者单位： | 1. 上海理工大学,医疗器械学院,上海,200093 2. 上海理工大学,动力工程学院,上海,200093 3. 复旦大学,药学院,上海,200032 |
| 基金项目： | 国家自然科学基金资助项目(50376040)，上海市教委重点学科建设资助项目 |
| 摘 要： | 研究了压力对乙基纤维素空白微粒粒径，以及阿莫西林-乙基纤维素-卡波谱缓释、黏附微粒性能的影响．实验表明乙基纤维素空白微粒和药物缓释、黏附微粒的粒径均随压力的升高而减小，但药物微粒的载药量和释放度曲线随压力的变化不明显。 |
| 关 键 词： | 增强溶液分散度法 超临界流体 乙基纤维素 阿莫西林 微粒 |
| 文章编号： | 1007-6735(2004)03-0220-04 |
| 修稿时间： | 2003-11-18 |
Pressure effects on drug microparticle formation by using supercritical fluid technology |
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| CHEN Lan~,ZHANG Yan~,LI Bao-guo~,WU Yi-wen~,HUA Ze-zhao~,LIU Zhe-peng~. Pressure effects on drug microparticle formation by using supercritical fluid technology[J]. Journal of University of Shanghai For Science and Technology, 2004, 26(3): 220-223 | |
| Authors: | CHEN Lan~ ZHANG Yan~ LI Bao-guo~ WU Yi-wen~ HUA Ze-zhao~ LIU Zhe-peng~ |
| Affiliation: | CHEN Lan~1,ZHANG Yan~2,LI Bao-guo~2,WU Yi-wen~2,HUA Ze-zhao~2,LIU Zhe-peng~3 |
| Abstract: | The pressure is one of the most important factors affecting the microparticle formation when using the techmique of solution enhanced dispersion with supercritical fluids (SEDS).The relation between the microparticle's diameters of ethylcellulose and the pressure is studied,and the influences of pressure on the characteristics of amoxcillin-ethylcellulose-carbopol particles are investigated as well.It can be concluded that the diameters of the ethylcellulose microparticles and the sustained-release and adhesive drug particles decrease with the increase of pressure,but the drug contents and drug release curves are almost the same under two different pressures. |
| Keywords: | solution enhanced dispersion supercritical fluids ethylcellulose amoxicillin microparticle |
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