| 小直径血管支架的仿生构建及其种子细胞 |
| |
| 引用本文： | 张超颖,李敏. 小直径血管支架的仿生构建及其种子细胞[J]. 福建师范大学学报(自然科学版), 2012, 28(5): 119-124 |
| |
| 作者姓名： | 张超颖 李敏 |
| |
| 作者单位： | 福建师范大学生命科学学院,福建福州,350108 |
| |
| 基金项目： | 福建省科技厅重点资助项目 |
| |
| 摘 要： | 静电纺丝仿生天然细胞外基质(ECM)结构,所制备的高度多孔、高比表面积的纳米级(50～500nm)纤维赋予了丰富的分子架构和生化信号,为种子细胞提供理想的生长微环境.不同组分、纤维尺寸及取向和种子细胞类型,可以裁剪获得不同生化和力学性能的电纺支架细胞复合物.总结了血管组织工程仿生ECM的设计与构建,并强调与支架复合的种子细胞在血管组织工程的作用.
|
| 关 键 词： | 血管组织工程 仿生ECM 静电纺丝 纳米纤维 种子细胞 细胞支架相互作用 |
Biomimetic Construction and Seed Cells of Small Diameter Vascular Scaffolds |
| |
| ZHANG Chao-ying , LI Min. Biomimetic Construction and Seed Cells of Small Diameter Vascular Scaffolds[J]. Journal of Fujian Teachers University(Natural Science), 2012, 28(5): 119-124 |
| |
| Authors: | ZHANG Chao-ying LI Min |
| |
| Affiliation: | (College of Life Sciences,Fujian Normal University,Fuzhou 350108,China) |
| |
| Abstract: | Electrospinning can produce a nanoscale fibers with macroporous as well as high surface area to volume ratio.These nanofibers closely resemble the structure and size scale of the native ECM(50 to 500 nm) endowed with both topographical and biochemical signals may provide an optimal microenvironment for the seeded cells.With various compositions,fiber dimensions,fiber orientations and seed cells types,the chemical,biological and mechanical properties of the electrospun scaffolds can be tailored.This covers the design and control of the electrospun biomimetic ECM process,and highlights the role of seed cells on scaffolds in the vascular tissue engineering. |
| |
| Keywords: | vascular tissue engineering extracellular matrix analogue electrospinning nanofibrous seed cells cell scaffold interactions |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
