| 人工牛黄甲硝唑胶囊贮存期的热分析动力学 |
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| 引用本文： | 张名楠,谢艳丽,王镇江.人工牛黄甲硝唑胶囊贮存期的热分析动力学[J].海南大学学报(自然科学版),2011,29(4):343-346. |
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| 作者姓名： | 张名楠 谢艳丽 王镇江 |
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| 作者单位： | 1. 海南省精细化工重点实验室,海南 海口 570228;海南大学分析测试中心,海南 海口 570228
2. 海南大学教务处,海南 海口,570228 |
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| 基金项目： | 海南大学材料与化工学院青年基金项目 |
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| 摘 要： | 采用热重法和微分热重法研究了药物人工牛黄甲硝唑胶囊在空气流中的热稳定性,根据热分析实验数据,采用3种利用热分析获取动力学参数的方法(Coats-Redfern法、Kissinger法和Ozawa法),计算人工牛黄甲硝唑热分解反应活化能E及频率因子A,并进行比较.结果表明,采用不同的处理方法,得出的热分解动力学参数不同,...
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| 关 键 词： | 人工牛黄甲硝唑胶囊 热分析动力学 贮存期 |
Thermal Analysis Study for Prediction of Galculus Bovis and Metronidazole Capsules Shelf-Time |
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| ZHANG Ming-nan
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XIE Yan-li
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WANG Zhen-jiang.Thermal Analysis Study for Prediction of Galculus Bovis and Metronidazole Capsules Shelf-Time[J].Natural Science Journal of Hainan University,2011,29(4):343-346. |
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| Authors: | ZHANG Ming-nan XIE Yan-li WANG Zhen-jiang |
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| Institution: | 1.Hainan Provincial Key Lab of Fine Chem,Haikou 570228,China; 2.Chemical Analytical and Testing Center,Hainan University,Haikou 570228,China; 3.Educational administration office,Hainan University,Haikou 570228,China) |
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| Abstract: | Thermogravimetry(TG) and differential thermogravimetry(DTG) technique were performed to study the thermal stabilities of Galculus Bovis and Metronidazole Capsules in atmosphere.Based on the thermal analysis data,three methods(Coats Redfern,Kissinger and Ozawa) were used to determine the kinetic parameters including activation energy E and frequency factor A.The results indicated that the kinetic parameters obtained by different method were different,and the thermal analysis was a quick,scientific and economical method to study the thermal stabilities of drugs and predict the shelf time of drugs. |
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| Keywords: | Galculus Bovis and Metronidazole Capsules thermal analysis kinetic shelf-time |
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