An antiviral factor fromMelia azedarach L. prevents Tacaribe virus encephalitis in mice |
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| Authors: | G M Andrei J S Lampuri C E Coto R A de Torres |
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| Institution: | (1) Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, piso 4, Ciudad Universitaria, 1428 Buenos Aires, (Argentina);(2) Departamento de Microbiología e Inmunología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, 1113 Buenos Aires, (Argentina) |
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| Abstract: | Summary Treatment of neonatal mice with an antiviral factor, (AVF), obtained from the leaves ofMelia azederach L. protected them against lethal encephalitis caused by Tacaribe virus inoculation. The degree of protection obtained varied from 66% to 100% depending on the virus dose. Similarly, administration of AVF to nursing mothers protected their offspring from developing virus encephalitis. AVF does not directly inactivate Tacaribe virus; it inhibits an early step (s) in the replication process in cell cultures.Dedicated to Prof. Luis Leloir on his 80th birthday.Acknowledgment. This study was supported by Grant 9353/84 from the Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Argentina. |
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| Keywords: | Antiviral activity Tacaribe virus Melia azedarach L arenavirus viral encephalitis |
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