Aquaporins with selectivity for unconventional permeants |
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Authors: | B Wu E Beitz |
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Institution: | (1) Department of Pharmaceutical Chemistry, University of Kiel, Gutenbergstrasse 76, 24118 Kiel, Germany |
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Abstract: | The aquaporin protein family generally seems to be designed for the selective passage of water or glycerol. Charged molecules,
metal ions and even protons are strictly excluded. Recently, particular aquaporin isoforms were reported to conduct unconventional
permeants, i.e., the unpolar gases carbon dioxide and nitric oxide, the polar gas ammonia, the oxidative oxygen species hydrogen peroxide,
and the metalloids antimonite, arsenite and silicic acid. Here, we summarize the available data on permeability properties
and physiological settings of these aquaporins and we analyze which structural features might be connected to permeability
for non-water, non-glycerol solutes.
Received 31 March 2007; received after revision 3 May 2007; accepted 23 May 2007 |
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Keywords: | Aquaporin aquaglyceroporin carbon dioxide nitric oxide hydrogen peroxide ammonia arsenite silicon |
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