甲硝唑芬布芬胶囊中甲硝唑含量的电化学研究

用预镀铋膜玻碳电极,采用差分脉冲溶出伏安法测定甲硝唑芬布芬胶囊中甲硝唑的含量。预镀铋膜玻碳电极提高了甲硝唑的电化学响应,出峰好,灵敏度高,且具有较好的稳定性。实验结果表明:在支持电解质0.60 mol/L的KCl和PBS(pH=7.00)中于电沉积电位为-250 mV下搅拌富集120 s后,可获一灵敏的阳极溶出峰,利用此法测定甲硝唑的检出限D=3.6×10-7mol/L,线性范围为(0.17~1.03)×10-3mg/mL,线性方程I=0.089 1 c+4×10-5,相关系数r=0.998 7,相对标准偏差RSD=4.00%,样品B的加标回收率为94.18%~102.27%,结果令人满意。

Electrochemistry Researchon Metronidazole and Fenbufen Capsules Metronidazole Content

The bismuth film electrode in differential pulse stripping analysis for the determintation of metronidazole in galculus bovis and metronidazole capsules was proposed.The bismuth film electrode,compared with at bare GOE,enhanced significantly,had high sensitive and displayed well-defined peak.In a supporting solution of 0.60 mol/L KCl and PBS(pH=7.00),the concentration potential of the metronidazole in-250 mV for 120 s enhanced anodic stripping peak current.The experiment results showed a high response,a good linear range(between 0.17 mg / mL ~ 1.03 × 10-3 mg / mL),a good precision(RSD = 4.00%) and a low detection limit 3.6 × 10-7 mol / L.Under optimum conditions,The equation of linear regression is I = 0.0891c + 0.00004,correlation coefficient r = 0.9987.The recovery range from 94.18% ~ 102.27%.The result is satisfactory.