Effects of blood sampling,anesthesia and surgery on plasma vasopressin concentration in rats |
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Authors: | B Corman G Geelen |
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Institution: | (1) Service de Biologie Cellulaire, Département de Biologie Cellulaire et Moléculaire, CEN Saclay, F-91 191 Gif-sur-Yvette;(2) Laboratoire de Physiologie de l'Environnement, Faculté de Médecine Grange-Blanche, 8 av. Rockefeller, F-69 373 Lyon, (France) |
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Abstract: | The influence of blood sampling, anesthesia and surgery on plasma vasopressin concentration was assessed in rats. Mean plasma concentration in conscious, chronically catheterized rats was 1.4±0.1 pg/ml (n=6). This value remained constant over repeated plasma samplings in the same animals. On the other hand, decapitation increased the plasma vasopressin concentration to 6.0±2.4 (in pg/ml) (n=6), inactin anesthesia to 2.9±0.6 (n=6), anesthesia and femoral cannulation to 13.3±5.8 (n=6) and surgery for renal micropuncture to 81.3±35.0 (n=6). It is concluded that the level of circulating plasma vasopressin is highly dependent on the sampling technique and is closely related to the extent of surgery. |
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Keywords: | Vasopressin rats surgery renal micropuncture anesthesia |
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