Genetic characterization of the new morphological and UV-sensitive mutants inCoprinus cinereus. I. A UV-sensitive mutationrad1 associated with elevated frequencies of mitotic and meiotic recombination

Summary Studies on the effect of an UV-sensitive mutation,rad1, in meiotic and mitotic recombination inCoprinus indicated that, in homozygous condition,rad1 increased the spontaneous meiotic recombination by 50% and UV-induced mitotic intergenic recombination by about 5-fold. The homozygousrad1 diploid was shwon to be much more sensitive to the recombinogenic effects of polyfunctional than of mono- or non-functional alkylating agents.This research, carried out in partial fulfilment of Ph.D. requirements at the University of London, was supported by a grant from The School of Public Health, University of Tehran, Iran. My thanks are due to Dr J.W. Cowan for his advice and constructive criticism. I am also indebted to Dr A.B. Borkovec of The Institute of Chemosterilants Laboratory, US Ministry of Agriculture for the most generous supply of aziridinyl phosphine compounds.