The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells |
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Authors: | G. Tesoriere L. Tesoriere R. Vento M. Giuliano G. Cantoro |
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Affiliation: | (1) Istituto di Chimica Biologica, Università di Palermo, Policlinico, I-90127 Palermo, (Italy) |
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Abstract: | Summary D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos. |
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