| 4-氯代异喹啉类衍生物的合成与表征 |
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| 引用本文： | 张红萍,李红艳,邓习文,张文婷.4-氯代异喹啉类衍生物的合成与表征[J].邵阳学院学报(自然科学版),2013(1):43-48. |
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| 作者姓名： | 张红萍 李红艳 邓习文 张文婷 |
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| 作者单位： | 邵阳学院生物与化学工程系 |
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| 基金项目： | 湖南省高等学校科学研究优秀青年项目(NO.10B097);湖南省科技厅计划项目(2011FJ4130)资助;邵阳学院科技创新团队(2012年)资助 |
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| 摘 要： | 在PdCl2／CuCl2／Cy2NH2Cl的催化体系中，邻炔基苄基叠氮可以顺利地发生亲电环化反应选择性合成3-取代-4-氯代异喹啉，产率38％-84％，其结构经1HNMR，13CNMR和GC-MS表征．该方法反应条件温和、操作简单，并且在产物骨架中引入卤原子，为新官能团的引入提供了途径．
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| 关 键 词： | 邻炔基苄基叠氮化合物 亲电环化 氯代异喹啉 |
Synthesis and Characterization of 4-Chloroisoquinolines |
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| ZHANG Hong-ping,LI Hong-yan,DENG Xi-wen,ZHANG Wen-ting.Synthesis and Characterization of 4-Chloroisoquinolines[J].Journal of Shaoyang University:Science and Technology,2013(1):43-48. |
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| Authors: | ZHANG Hong-ping LI Hong-yan DENG Xi-wen ZHANG Wen-ting |
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| Institution: | (Department of Biology and Chemistry Engineering,Shaoyang University,Shaoyang,Hunan 422000,China) |
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| Abstract: | In the presence of PdCl2/CuCl2/Cy2NH2Cl, a variety of 2-alkynyl benzyl azides smoothly underwent the electronic cyelization to afford the corresponding 3-substituted 4-chloroisoquinolines in 38% -84% yields. The structures were confirmed by 1H NMR, 13C NMR and GC-MS. This method had many merits such as simple operation and mild reaction condition. Importantly, a halide was introduced into the products which makes the methodology more attractive for organic synthesis. |
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| Keywords: | 2-alkynyl benzyl azides eleetrophilie cyelization ehloroisoquinolines |
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