Effets d'analogues du chloramphénicol sur la différenciation de l'∄uf de l'oursinParacentrotus lividus |
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Authors: | R Lallier |
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Institution: | (1) Station Zoologique, 06 Villefranche-sur-Mer, France |
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Abstract: | Summary The effects ofl-threo-chloramphenicol and thiophenicol on the differentiation of sea-urchin eggs are compared with those exerted byd-threo-chloramphenicol. Onlyd-threo-chloramphenicol caused vegetalization;l-threo-chloramphenicol inhibited development. These effects resemble those of nitrobenzene. Thiophenicol, differing fromd-threo-chloramphenicol by replacing the nitro group with a methylsulphonyl group, slows down development at high concentrations. The effects of chloramphenicol on oxidative phosphorylation and synthesis of proteins are discussed. It is suggested that both the steric configuration typed-threo of the side chain and the presence of a nitro group are necessary for the vegetalizing activity. |
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