| 抗心律失常新药多非利特的合成 |
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| 引用本文： | 赵洪光,许崇娟,戚玉华. 抗心律失常新药多非利特的合成[J]. 济南大学学报(自然科学版), 2005, 19(2): 163-165 |
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| 作者姓名： | 赵洪光 许崇娟 戚玉华 |
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| 作者单位： | 济南大学,化学化工学院,山东,济南,250022;济南大学,化学化工学院,山东,济南,250022;济南大学,化学化工学院,山东,济南,250022 |
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| 摘 要： | 以2-(4-硝基苯基)乙酸为主要原料，经酰氯化、N-酰化、还原、N-烷基化、氢化还原、甲磺酰化制得抗心率失常新药多非利特，总收率为17．4％。所得化合物的结构由元素分析、^1H—NMR、IR和MS确证。
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| 关 键 词： | 多非利特 抗心律失常药 合成 |
| 文章编号： | 1671-3559(2005)02-0163-03 |
| 修稿时间： | 2004-04-06 |
Synthesis of Dofetilide as a Novel Antiarrhythmic Agent |
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| ZHAO Hong-guang,XU Chong-juan,QI Yu-Hua. Synthesis of Dofetilide as a Novel Antiarrhythmic Agent[J]. Journal of Jinan University(Science & Technology), 2005, 19(2): 163-165 |
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| Authors: | ZHAO Hong-guang XU Chong-juan QI Yu-Hua |
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| Abstract: | Dofetilide was synthesized as a novel antiarrhythmic agent in this paper.2-(4-Nitrophenyl)acetate acid was used as a main material to react by chlorization,N-acidation,reduction,N-alkylation,catalytic hydrogenation and methanesulfonylation to produce dofetilide with an over yield of 17.4%.The structure of dofetilide was confirmed through elemental analysis,~ 1H-NMR,IR and MS spectra. |
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| Keywords: | dofetilide antiarrhythmic agent synthesis |
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