Toll-like receptors in the induction of the innate immune response |
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Authors: | Aderem A Ulevitch R J |
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Institution: | Department of Immunology, University of Washington, Seattle 98195, USA. |
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Abstract: | The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence. |
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