| 中国人血管紧张肽原基因M235T多态位点与原发性高血压的关联分析 |
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| 引用本文： | 肖君华,郭文俊,刘木根,单如群,梅天一,柴建华.中国人血管紧张肽原基因M235T多态位点与原发性高血压的关联分析[J].复旦学报(自然科学版),1998(2). |
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| 作者姓名： | 肖君华 郭文俊 刘木根 单如群 梅天一 柴建华 |
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| 作者单位： | 复旦大学遗传工程国家重点实验室(肖君华，郭文俊，刘木根，单如群，柴建华)，锡山市雪浪红十字医院(梅天一) |
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| 摘 要： | 研究了中国汉族自然群体中血管紧张肽原基因（ＡＧＴ）Ｍ２３５Ｔ多态位点在原发性 高血压患者和同龄对照者之间的等位频率分布．观察到ＡＧＴ基因的Ｍ２３５Ｔ位在中国汉族 人群中存在两个等位因子的遗传多态性（Ｍ２３５／２３５Ｔ），其杂合率（ｈｅｔｅｒｏｚｙｇｏｓｉｔｙ）为３０％． Ｔ２３５基因在高血压群体中为８８．７％，在正常人群的频率为７９．０％，两者有显著性差异（ｘ２＝ ６．２６４，ｐ＜０．０２）．提示中国人血管紧张肽原基因（ＡＧＴ）Ｍ２３５Ｔ多态位点与原发性高血压之 间有显著关联．
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| 关 键 词： | 原发性高血压 AGT基因 关联分析 |
Association Analysis of AGT M235T Polymorphic Site and Essential Hypertension in Chinese Population |
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| Xiao Junhua, Guo Wenjun, Liu Mugeng, Shan Ruqun, Mei Tianyi, Chai Jianhua.Association Analysis of AGT M235T Polymorphic Site and Essential Hypertension in Chinese Population[J].Journal of Fudan University(Natural Science),1998(2). |
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| Authors: | Xiao Junhua Guo Wenjun Liu Mugeng Shan Ruqun Mei Tianyi Chai Jianhua |
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| Abstract: | Allele frequency a polymorphic site (M235T) in AGT gene was studied in the patients with essential hypertension (EH) and the controls with matching age. M235T is a diallelic polymorphism with heterozygosity beng 30%. The frequency of allele T235 is 88. 7% in the EH patients and 79. 0% in the control population. The difference between two populations is statistically significant (p<0. 02)suggesting the association of M235T in AGT gene and EH in the Chinese population studied, whch either implies direct involvment of the polymorphic site in EH or Close linkage between M235T site and the gene causing the disease. |
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| Keywords: | essential hypertension AGT gene association analysis |
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