| 牛肾上腺髓质8-22肽增强吗啡的抗伤害作用 |
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| 引用本文： | 江剑平,付艳,张文华,洪炎国. 牛肾上腺髓质8-22肽增强吗啡的抗伤害作用[J]. 福建师范大学学报(自然科学版), 2009, 25(2) |
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| 作者姓名： | 江剑平 付艳 张文华 洪炎国 |
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| 作者单位： | 福建师范大学生命科学学院,福建省发育和神经生物学重点实验室,福建,福州,350108 |
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| 基金项目： | 国家自然科学基金，福建省自然科学基金，福建师范大学优秀青年骨干教师培养基金 |
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| 摘 要： | 采用甩尾反射实验研究椎管内注射感觉神经元特异性受体的激动剂牛肾上腺髓质8-22肽(bovine adrenal medulla 8-22,BAM8-22)对吗啡抗伤害作用的影响.结果表明,BAM8-22本身并不能改变伤害性热刺激引起的甩尾反射潜伏期,但与吗啡混合使用时,能明显增强吗啡的抗伤害作用.0.1,1,10 nmol BAM8-22与0.3 μg 吗啡混合进行椎管内注射,能剂量依赖地增强吗啡的抗伤害作用.0.1 nmol BAM8-22分别与0.2,1,5 μg吗啡混合进行椎管内注射后,吗啡的抗伤害作用分别为35.1%,61.8%,72.7%,明显高于吗啡对照组的13.0%,30.7%,52.8%(P＜0.01).本研究表明,BAM8-22能增强吗啡的抗伤害作用,暗示感觉神经元特异性受体(SNSR)参与调制阿片受体的抗伤害过程.
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| 关 键 词： | 牛肾上腺髓质8-22肽(BAM8-22) 吗啡 抗伤害作用 |
Bovine Adrenal Medulla 8-22 Enhances Morphine Antinociception in Rats |
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| JIANG Jian-ping,FU Yan,ZHANG Wen-hua,HONG Yan-guo. Bovine Adrenal Medulla 8-22 Enhances Morphine Antinociception in Rats[J]. Journal of Fujian Teachers University(Natural Science), 2009, 25(2) |
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| Authors: | JIANG Jian-ping FU Yan ZHANG Wen-hua HONG Yan-guo |
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| Affiliation: | College of Life Sciences;Fujian Normal University;Key Laboratory of Developmental and Neurological Biology of Fujian Province;Fuzhou 350108;China |
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| Abstract: | To designed investigate the effect of intrathecal(i.t.) administration of bovine adrenal medulla 8-22(BAM8-22),an agonist of sensory neuron-specific receptors,on the potency of morphine analgesia assessed by tail flick test.It was found that BAM8-22 alone did not alter the tail flick latency,but significantly enhanced the potency of morphine antinociception when the two agents were co-administered.BAM8-22(0.1,1,10 nmol,i.t.) produced a dose-dependent increase morphine antinoceception when it was co-administ... |
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