| 红细胞CR1数量表达和基因多态性的研究 |
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| 引用本文： | 闵永萃,汲晨锋. 红细胞CR1数量表达和基因多态性的研究[J]. 哈尔滨商业大学学报(自然科学版), 2008, 24(2): 143-148 |
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| 作者姓名： | 闵永萃 汲晨锋 |
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| 作者单位： | 哈尔滨商业大学,生命科学与环境科学研发中心,药物研究所博士后科研工作站,哈尔滨,150076;国家教育部,抗肿瘤天然药物工程研究中心,哈尔滨,150076 |
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| 基金项目： | 国家自然科学基金 , 黑龙江省哈尔滨市学科后备带头人基金 |
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| 摘 要： | 红细胞补体受体I（CR1）是红细胞重要的免疫物质基础,红细胞的一个功能是通过CR1促进免疫复合物由循环中完全清除.红细胞免疫黏附能力与CR1数量表达有关,CR1的基因突变影响数量表达.许多疾病如系统性红斑狼疮（SLE）、慢性肝炎及肿瘤中红细胞CR1水平下降,与CR1分子的数量及基因多态性密切相关.
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| 关 键 词： | 红细胞CR1 数量表达 基因多态性 |
| 文章编号： | 1672-0946(2008)02-0143-05 |
| 修稿时间： | 2007-07-16 |
Study on number expression and genomic polymorphism of CR1 on erythrocyte |
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| MIN Yong-cui,JI Chen-feng. Study on number expression and genomic polymorphism of CR1 on erythrocyte[J]. Journal of Harbin University of Commerce :Natural Sciences Edition, 2008, 24(2): 143-148 |
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| Authors: | MIN Yong-cui JI Chen-feng |
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| Affiliation: | MIN Yong-cui,JI Chen-feng ( 1. Postdoctoral Programme of Insitiute of Matoria Medica of Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; 2. Engineering Research Center of Natural Anticancer Drugs, Ministry of Education,Harbin 150076, China) |
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| Abstract: | Erythrocyte Complement receptor type 1 （CR1） is the basis of important immune substance on E. One function of E is that CR1 advance elimination of immune complexes （IC） completely from the circulation. There is a correlation between the ability of erythrocytes immune adhering and the number of CR1, and CR1 genomic mutation affect the number. There is intimate association between the descending level of CR1 and the number of CR1 or CR1 in some diseases such as systemic lupus erythematosus （SLE）, chronic hepatitis and tumor. |
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| Keywords: | complement receptor type 1 number expression genomic polymorphism |
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