| 超临界CO2在制备PCL/水杨酸甲酯控释体系中的应用研究 |
| |
| 引用本文： | 胡银春,许群,李建波,后振中,范海娟.超临界CO2在制备PCL/水杨酸甲酯控释体系中的应用研究[J].世界科技研究与发展,2007,29(3):22-26. |
| |
| 作者姓名： | 胡银春 许群 李建波 后振中 范海娟 |
| |
| 作者单位： | 郑州大学材料科学与工程学院,郑州,450052 |
| |
| 摘 要： | 本文利用超临界二氧化碳（SCCO2）对生物可降解材料--聚己内酯（PCL）进行溶胀和塑化,进而将其作为携带剂,将水杨酸甲酯嵌入到PCL中,制备含有水杨酸甲酯的PCL多孔材料,即PCL/水杨酸甲酯控释体系,并研究超临界流体条件下水杨酸甲酯的插嵌规律.研究结果表明,PCL对水杨酸甲酯有很好的吸附能力,通过测定所制备的多孔材料PCL/水杨酸甲酯体系的缓释行为,表明其多孔结构对药物分子具有一定的缓释功能,药物分子释放时间最长可达18 h以上.
|
| 关 键 词： | 超临界二氧化碳 聚己内酯 水杨酸甲酯 缓释材料 |
The Assistance of Supercritical Carbon Dioxide in the Preparation of PCL/Methyl Salicylate Controlled-Release System |
| |
| HU Yinchun,XU Qun,LI Jianbo,HOU Zhenzhong,FAN Haijuan.The Assistance of Supercritical Carbon Dioxide in the Preparation of PCL/Methyl Salicylate Controlled-Release System[J].World Sci-tech R & D,2007,29(3):22-26. |
| |
| Authors: | HU Yinchun XU Qun LI Jianbo HOU Zhenzhong FAN Haijuan |
| |
| Institution: | College of Materials Engineering, Zhengzhou University, Zhengzhou 450052 |
| |
| Abstract: | In this study,poly(e-caprolactone)(PCL),which was chosen as the polymer matrix,was swelled and plasticized in supercritical carbon dioxide(SC CO2).Then drug precursor methyl salicylate(MS) was impregnated and encapsulated into PCL using SC-CO2 as a carrier and swelling agent.The effects of temperature,pressure and concentration of drug precursor on drug loading amount were studied.The release behaviors of the controlled-release systems with different drug loading amounts were also investigated. |
| |
| Keywords: | supercritical carbon dioxide polycaprolactone methyl sallcylate controlled-release material |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
